Gisborne
Multi-Atlas Brain Network Classification through Consistency Distillation and Complementary Information Fusion
Xu, Jiaxing, Lan, Mengcheng, Dong, Xia, He, Kai, Zhang, Wei, Bian, Qingtian, Ke, Yiping
In the realm of neuroscience, identifying distinctive patterns associated with neurological disorders via brain networks is crucial. Resting-state functional magnetic resonance imaging (fMRI) serves as a primary tool for mapping these networks by correlating blood-oxygen-level-dependent (BOLD) signals across different brain regions, defined as regions of interest (ROIs). Constructing these brain networks involves using atlases to parcellate the brain into ROIs based on various hypotheses of brain division. However, there is no standard atlas for brain network classification, leading to limitations in detecting abnormalities in disorders. Some recent methods have proposed utilizing multiple atlases, but they neglect consistency across atlases and lack ROI-level information exchange. To tackle these limitations, we propose an Atlas-Integrated Distillation and Fusion network (AIDFusion) to improve brain network classification using fMRI data. AIDFusion addresses the challenge of utilizing multiple atlases by employing a disentangle Transformer to filter out inconsistent atlas-specific information and distill distinguishable connections across atlases. It also incorporates subject- and population-level consistency constraints to enhance cross-atlas consistency. Additionally, AIDFusion employs an inter-atlas message-passing mechanism to fuse complementary information across brain regions. Experimental results on four datasets of different diseases demonstrate the effectiveness and efficiency of AIDFusion compared to state-of-the-art methods. A case study illustrates AIDFusion extract patterns that are both interpretable and consistent with established neuroscience findings.
Contrasformer: A Brain Network Contrastive Transformer for Neurodegenerative Condition Identification
Xu, Jiaxing, He, Kai, Lan, Mengcheng, Bian, Qingtian, Li, Wei, Li, Tieying, Ke, Yiping, Qiao, Miao
Understanding neurological disorder is a fundamental problem in neuroscience, which often requires the analysis of brain networks derived from functional magnetic resonance imaging (fMRI) data. Despite the prevalence of Graph Neural Networks (GNNs) and Graph Transformers in various domains, applying them to brain networks faces challenges. Specifically, the datasets are severely impacted by the noises caused by distribution shifts across sub-populations and the neglect of node identities, both obstruct the identification of disease-specific patterns. To tackle these challenges, we propose Contrasformer, a novel contrastive brain network Transformer. It generates a prior-knowledge-enhanced contrast graph to address the distribution shifts across sub-populations by a two-stream attention mechanism. A cross attention with identity embedding highlights the identity of nodes, and three auxiliary losses ensure group consistency. Evaluated on 4 functional brain network datasets over 4 different diseases, Contrasformer outperforms the state-of-the-art methods for brain networks by achieving up to 10.8\% improvement in accuracy, which demonstrates its efficacy in neurological disorder identification. Case studies illustrate its interpretability, especially in the context of neuroscience. This paper provides a solution for analyzing brain networks, offering valuable insights into neurological disorders. Our code is available at \url{https://github.com/AngusMonroe/Contrasformer}.
The correlation between nativelike selection and prototypicality: a multilingual onomasiological case study using semantic embedding
In native speakers' lexical choices, a concept can be more readily expressed by one expression over another grammatical one, a phenomenon known as nativelike selection (NLS). In previous research, arbitrary chunks such as collocations have been considered crucial for this phenomenon. However, this study examines the possibility of analyzing the semantic motivation and deducibility behind some NLSs by exploring the correlation between NLS and prototypicality, specifically the onomasiological hypothesis of Grondelaers and Geeraerts (2003, Towards a pragmatic model of cognitive onomasiology. In Hubert Cuyckens, Ren\'e Dirven & John R. Taylor (eds.), Cognitive approaches to lexical semantics, 67-92. Berlin: De Gruyter Mouton). They hypothesized that "[a] referent is more readily named by a lexical item if it is a salient member of the category denoted by that item". To provide a preliminary investigation of this important but rarely explored phenomenon, a series of innovative methods and procedures, including the use of semantic embedding and interlingual comparisons, is designed. Specifically, potential NLSs are efficiently discovered through an automatic exploratory analysis using topic modeling techniques, and then confirmed by manual inspection through frame semantics. Finally, to account for the NLS in question, cluster analysis and behavioral profile analysis are conducted to uncover a language-specific prototype for the Chinese verb shang 'harm', providing supporting evidence for the correlation between NLS and prototypicality.
Data-Driven Network Neuroscience: On Data Collection and Benchmark
Xu, Jiaxing, Yang, Yunhan, Huang, David Tse Jung, Gururajapathy, Sophi Shilpa, Ke, Yiping, Qiao, Miao, Wang, Alan, Kumar, Haribalan, McGeown, Josh, Kwon, Eryn
This paper presents a comprehensive and quality collection of functional human brain network data for potential research in the intersection of neuroscience, machine learning, and graph analytics. Anatomical and functional MRI images have been used to understand the functional connectivity of the human brain and are particularly important in identifying underlying neurodegenerative conditions such as Alzheimer's, Parkinson's, and Autism. Recently, the study of the brain in the form of brain networks using machine learning and graph analytics has become increasingly popular, especially to predict the early onset of these conditions. A brain network, represented as a graph, retains rich structural and positional information that traditional examination methods are unable to capture. However, the lack of publicly accessible brain network data prevents researchers from data-driven explorations. One of the main difficulties lies in the complicated domain-specific preprocessing steps and the exhaustive computation required to convert the data from MRI images into brain networks. We bridge this gap by collecting a large amount of MRI images from public databases and a private source, working with domain experts to make sensible design choices, and preprocessing the MRI images to produce a collection of brain network datasets. The datasets originate from 6 different sources, cover 4 brain conditions, and consist of a total of 2,702 subjects. We test our graph datasets on 12 machine learning models to provide baselines and validate the data quality on a recent graph analysis model. To lower the barrier to entry and promote the research in this interdisciplinary field, we release our brain network data and complete preprocessing details including codes at https://doi.org/10.17608/k6.auckland.21397377 and https://github.com/brainnetuoa/data_driven_network_neuroscience.